2 edition of Rational redesign and characterisation of a peptide-based fibre found in the catalog.
Rational redesign and characterisation of a peptide-based fibre
Andrew Mark Smith
Written in English
D.Phil. 2002 BLDSC DXN062193.
|Statement||Andrew Mark Smith.|
|Series||Sussex theses ; S 5470|
|The Physical Object|
|Number of Pages||206|
Document - Document The main conclusion is that the test methods currently used do not guarantee a coherent set of mechanical properties useful for numerical simulation, which highlights the need to define new characterisation methods better adapted to the behaviour of FDM-printed PLA PB - MDPI AG TI - Elastic asymmetry of PLA material in FDM-printed parts. pages/ none This application is related to a PhD project within the MIRACLE project (InterMedia, University of Oslo), which is financed by the VERDIKT program. The ti. The results will be compiled in a Cook Book with best practice and recommendations for replication in other regions. The commitment is dependent upon the availability of funding recently applied for under the DG SANCO Health programme, to cover the overhead costs related to its implementation [email protected]
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A.M. Smith, Rational Redesign and Characterisation of a Peptide-based Fibre, Ph.D. thesis, University of Sussex, Towards an Atomistic Structure of a De Novo Designed Peptide Fibre. In: Rational redesign and characterisation of a peptide-based fibre book Imaging at High Spatial and Temporal Resolution In Vitro and In Vivo.
Author: Thomas Harry Sharp. Two stages in the rational redesign of a peptide-based, self-assembling fiber (SAF) are described. The SAF system comprises two peptides designed to form an offset a-helical coiled-coil heterodimer. In addition to the earlier follow-up papers detailing improvements to Rational redesign and characterisation of a peptide-based fibre book design and more-detailed characterisation of fibres [15, 16], Kajava and colleagues have recently reported that the αFFP system can be supplemented to incorporate the cell-binding peptide moiety, RGD, to support cell growth in culture [17 •].Conticello and colleagues have followed up their work on the YZ1 Cited by: stand protein folding, and, therefore, the rational design of protein structure and function is in its infancy.3,4 This chapter focuses on supramolecular assemblies that are formed using a variety of de novo designed peptide-based tectons.
A brief introduction to amino acids (the building blocks of peptides and proteins) is given, followed. Rational design of peptide-based building blocks for nanoscience and synthetic biology Article PDF Available. Biophysical characterisation.
Diverse cellular events such as protein and vesicle trafficking, gene expression, DNA repair, control of the cytoskeleton and targeted protein degradation as well as signaling cascades are regulated through dynamic protein interactions .Enhancing the efficacy of a peptide therapeutic addressing one of these processes is tightly bound to basic principles governing Cited by: 6.
Nature’s own building block, peptide/protein derived materials have been of great interest for supramolecular chemists. The amino acids in peptides/proteins are linked via amide bonds, which makes them more stable against degradation as compared to other natural materials such as oligonucleotides.
New Biodegradable Peptide-based Polymer Constructs Maarten van Dijk PhD thesis with summary in Dutch Department of Medicinal Chemistry and Chemical Biology and Department of.
Peptide-based materials constitute a class of molecules that play an important role in many biological processes and are utilized by many organisms to interact with their environment. One of the most well-known examples is spider silk, a material produced by web Author: S.
van der Wal. Peptide-based therapeutics have been an active area of research for a number of years. They have been found applications as drug-delivery agents, anticancer therapies and as antibiotics, the latter of which is particularly notable when set against a present-day backdrop of the increasing problem of antibiotic resistance.
However, the use of peptides is still limited as they suffer from Author: Alexandra Margaret Webster. peptide-based materials, operating at the interface of chemistry, biology and physics.
Leunissen Elizabeth H. Leunissen re-ceived her Bachelor’s degree in molecular life sciences at the Radboud University Nijmegen in She performed her Master’s research on a cell penetrating peptide mediated delivery system in the group.
The development of small molecules that can efficiently gel water is of great interest for researchers in the field of recently found that a short peptide-based molecule (Nap-GFFpY-OMe) could form hydrogels at a minimum gelation concentration of wt% after enzymatic conversion, which was the most efficient small molecular hydrogelator reported up.
Peptide-based ﬁbrous biomaterials: some things old, new and borrowed Derek N Woolfson1,2 and Maxim G Ryadnov1 Bioinspired ﬁbrous materials that span the nano-to-meso scales have potentially broad applications in nanobiotechnology; for instance, as scaffolds in 3D cell culture and tissue engineering, and as templates for the assembly of.
This article explores recent advances in the design and engineering of materials wholly or principally constructed from peptides. We focus on materials that are able to respond to changes in their environment (pH, ionic strength, temperature, light, oxidation/reduction state, presence of small molecules or the catalytic activity of enzymes) by altering their macromolecular by: Porous materials find widespread application in storage, separation, and catalytic technologies.
We report a crystalline porous solid with adaptable porosity, in which a simple dipeptide linker is arranged in a regular array by coordination to metal centers. Experiments reinforced by molecular dynamics simulations showed that low-energy torsions and displacements of the peptides.
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In the past decade, polymersomes (also referred to as polymeric vesicles) have attracted rapidly growing interest based on their intriguing aggregation phenomena, cell and virus-mimicking dimensions and functions, as well as tremendous potential applications in medicine, pharmacy, and biotechnology.
Unlike liposomes self-assembled from low molecular weight lipids. §Ligands were selected on the basis of high affinity, from a peptide-based random synthesis with non-standard amino acid monomers. #Peptide PPPVPPRRR. **PPPALPPKKR. Structures were calculated by dynamical simulated annealing in the program X-PLOR , using a total of.
ANNUAL REPORT CONTENTS IMB is committed to improving quality of life for all by pursuing discoveries through fundamental research, inventing biotechnologies, and advancing cures for disease. The same principle can be used to deliver chemotherapy drugs directly to a tumor and activate them only when on site.
Nanotechnologies can also be applied to biomaterials. For example, soft tissue engineering can make use of nanoﬁbers, nanotubes, and peptide-based self-assembled nanostructures to form scaffolds promoting tissue growth .
Items where Year is () A peptide-based mechano-sensitive, proteolytically stable hydrogel with remarkable antibacterial properties. Langmuir, 32 (7). () Prebiotic potential of a maize-based soluble fibre and impact of dose on the human gut microbiota. PLoS ONE, 11 (1). e Kinetic data in batch reactors are generally represented by empirical models neglecting mass transfer effects (pseudo-first and pseudo-second-order models), while F.
Pagnanelli () Department of Chemistry, Sapienza University of Rome, A. Moro 5, Rome, Italy e-mail: [email protected] P. Kotrba et al. (eds.), Microbial Biosorption of. Banham, R., Kindel, E., Pané-Farré, P.
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Background. The discovery of RNA interference (RNAi) has changed the field of gene therapy. RNAi is a post-transcriptional gene silencing process that can specifically and potently knock down the expression of target genes both in vitro and in vivo [1, 2].RNAi can be induced by short interfering RNA (siRNA).
siRNAs are double stranded RNA fragments with 21–23 nucleotides Cited by: 7. Thus, by employing the techniques described here, which utilize the unique properties of specific short peptides derived from motifs found in full-length proteins, one may accelerate the identification of functional motifs in proteins and the development of peptide-based inhibitors of pathogenic by: 2.
Peptide amphiphiles are peptide-based molecules that self-assemble into structures including high aspect ratio nanofibers. A peptide amphiphile typically comprises a hydrophilic peptide sequence with an attached lipid chains, in this case being a lipopeptide. They were first described by the group of Matthew Tirrell in These molecules are often composed of multiple.
The hydrocarbon stapling technique combines two α-helix stabilisation strategies, namely α,α-disubstitution and macrocyclic bridge α,α-disubstituted residues bearing olefin side chains of varying lengths are introduced into the peptide α-helix, followed by a ruthenium-catalysed ring-closing metathesis reaction to form the staple across one or two α-helical turns Cited by: The computational design methods and stable scaffolds generated provide a promising starting point for the development of a new generation of peptide-based by: The complex nature of in vivo gene transfer establishes the need for multifunctional delivery vectors capable of meeting these challenges.
An additional consideration for clinical translation of synthetic delivery formulations is reproducibility and scale-up of materials. In this review, we summarize our work over the last five years in developing a modular Cited by: Encyclopedia of Bioprocess Technology or How to Improve Enzymes for Biocatalysis Fermentation, Biocatalysis, and Bioseparation February April isbn isbn I.
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SELF-ASSEMBLING PEPTIDE SYSTEMS IN BIOLOGY, MEDICINE AND ENGINEERING This page intentionally left blank. SELF-ASSEMBLING PEPTIDE SYSTEMS IN BIOLOGY, MEDICINE AND ENGINEERING edited by AMALIA AGGELI NEVILLE BODEN University of Leeds, United Kingdom and SHUGUANG ZHANG Massachusetts Institute of Technology, Cambridge, MA.
INTRODUCTION. A serious limitation of the use of many types of synthetic oligonucleotides (ON) and their analogues as therapeutic antisense agents has been their poor cellular delivery (1,2).Many types of vector have been designed to aid ON delivery both for cell culture and in t such strategies, conjugation to cell penetrating peptides (CPP) Cited by: Physical and transcriptional map in the CMT 1 A region.
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